Do Not Inject Me ! Say No To Vaccines

References:

1. Mercury vapour inhalation inhibits binding of GTP to tubulin in rat brain: similarity to a molecular lesion in Alzheimer diseased brain

Pendergrass JC, Haley BE, Vimy MJ, Winfield SA, Lorscheider FL.

Neurotoxicology. 1997;18(2):315-24.



Hg2+ interacts with brain tubulin and disassembles microtubules that maintain neurite structure. Since it is well known that Hg vapour (Hg0) is continuously released from "silver" amalgam tooth fillings and is absorbed into brain, rats were exposed to Hg0 4h/day for 0, 2, 7, 14 and 28 d at 250 or 300 micrograms Hg/m3 air, concentrations present in mouth air of some humans with many amalgam fillings. Average rat brain Hg concentrations increased significantly (11-47 fold) with duration of Hg0 exposure. By 14 d Hg0 exposure, photoaffinity labelling on the beta-subunit of the tubulin dimer with [alpha 32P] 8N3 GTP in brain homogenates was decreased 41-74%, upon analysis of SDS-PAGE autoradiograms. The identical neurochemical lesion of similar or greater magnitude is evident in Alzheimer brain homogenates from approximately 80% of patients, when compared to human age-matched neurological controls. Total tubulin protein levels remained relatively unchanged between Hg0 exposed rat brains and controls, and between Alzheimer brains and controls. Since the rate of tubulin polymerization is dependent upon binding of GTP to tubulin dimers, we conclude that chronic inhalation of low-level Hg0 can inhibit polymerization of brain tubulin essential for formation of microtubules.



2. Reduced levels of mercury in first baby haircuts of autistic children

Holmes AS, Blaxill MF, Haley BE.

Int J Toxicol. 2003 Jul-Aug;22(4):277-85.



Reported rates of autism have increased sharply in the United States and the United Kingdom. One possible factor underlying these increases is increased exposure to mercury through thimerosal-containing vaccines, but vaccine exposures need to be evaluated in the context of cumulative exposures during gestation and early infancy. Differential rates of postnatal mercury elimination may explain why similar gestational and infant exposures produce variable neurological effects. First baby haircut samples were obtained from 94 children diagnosed with autism using Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM IV) criteria and 45 age- and gender-matched controls. Information on diet, dental amalgam fillings, vaccine history, Rho D immunoglobulin administration, and autism symptom severity was collected through a maternal survey questionnaire and clinical observation. Hair mercury levels in the autistic group were 0.47 ppm versus 3.63 ppm in controls, a significant difference. The mothers in the autistic group had significantly higher levels of mercury exposure through Rho D immunoglobulin injections and amalgam fillings than control mothers. Within the autistic group, hair mercury levels varied significantly across mildly, moderately, and severely autistic children, with mean group levels of 0.79, 0.46, and 0.21 ppm, respectively. Hair mercury levels among controls were significantly correlated with the number of the mothers' amalgam fillings and their fish consumption as well as exposure to mercury through childhood vaccines, correlations that were absent in the autistic group. Hair excretion patterns among autistic infants were significantly reduced relative to control. These data cast doubt on the efficacy of traditional hair analysis as a measure of total mercury exposure in a subset of the population. In light of the biological plausibility of mercury's role in neurodevelopmental disorders, the present study provides further insight into one possible mechanism by which early mercury exposures could increase the risk of autism.



3. Mercury toxicity presenting as chronic fatigue, memory impairment and depression: diagnosis, treatment, susceptibility, and outcomes in a New Zealand general practice setting (1994-2006)

Wojcik DP, Godfrey ME, Christie D, Haley BE.

Neuro Endocrinol Lett. 2006 Aug;27(4):415-23.



In a group of 465 patients diagnosed as having chronic mercury toxicity (CMT), 32.3% had severe fatigue, 88.8% had memory loss, and 27.5% had depression. A significant correlation was found between CMT and the Apo-lipoprotein E4 genotype (p=0.001). An investigation into an additional 864 consecutively seen general practice patients, resulted in 30.3% having evidence consistent with CMT, and once again a significant correlation was found with the APO-E4 genotype (p=0.001). Removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p<0.001) to levels reported by healthy subjects.



4. Aluminium in vaccination-associated cognitive decline, motor neuron disease, autism

Teresa Binstock; Sept 28, 2009

http://www.generationrescue.org/binstock/090928-aluminum-als-alzheimer-autism.htm



5. Autism's genetic roots examined in new government-funded study

Melissa Healy, Los Angeles Times

September 30, 2009

http://latimesblogs.latimes.com/booster_shots/2009/09/autisms-genetic-roots-probed-by-new-governmentfunded-study.html



6. Hepatitis B triple series vaccine and developmental disability in US children aged 1-9 years

 Gallagher C, Goodman M. Toxicol Environ Chem 2008 90(5):997-1008.

{free online}

http://fourteenstudies.org/pdf/hep_b.pdf



7. Hepatitis B vaccination of male neonates and autism

CM Gallagher, MS Goodman

Annals of Epidemiology

Vol. 19, No. 9 ABSTRACTS (ACE)

September 2009: p. 659

Stony Brook University Medical Center, NY



PURPOSE: Universal newborn immunization with hepatitis B vaccine was recommended in 1991; however, safety findings are mixed. The Vaccine Safety Datalink Workgroup reported no association between hepatitis B vaccination at birth and febrile episodes or neurological adverse events. Other studies found positive associations between hepatitis B vaccination and ear infection, pharyngitis, and chronic arthritis; as well as receipt of early intervention/special education services (EIS); in probability samples of

U.S. children. Children with autistic spectrum disorder (ASD) comprise a growing caseload for EIS. We evaluated the association between hepatitis B vaccination of male neonates and parental report of ASD.

METHODS: This cross-sectional study used U.S. probability samples obtained from National Health Interview Survey 1997–2002 datasets. Logistic regression modeling was used to estimate the effect of neonatal hepatitis B vaccination on ASDrisk amongboys age 3–17 years with shot records, adjusted for race, maternal education, and two-parent household.

RESULTS:Boyswho received the hepatitis B vaccine during the first month of life had 2.94 greater odds for ASD (nZ31 of 7,486; OR Z 2.94; p Z 0.03; 95% CI Z 1.10, 7.90) compared to later- or unvaccinated boys. Non-Hispanicwhite boys were 61% less likely to have ASD(ORZ0.39; pZ0.04; 95% CIZ0.16, 0.94) relative to non-white boys.

CONCLUSION: Findings suggest that U.S. male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD; risk was greatest for non-white boys.



8. [Synopsis & review]

Blockbuster primate Study Shows Significant Harm from One Birth Dose of a Mercury-containing Vaccine

By Mark Blaxill; Sept 30, 2009

http://tinyurl.com/y9dvzae



9. Blood-brain barrier flux of aluminium, manganese, iron and  other metals suspected to contribute to metal-induced  neurodegeneration

Yokel RA.

J Alzheimers Dis. 2006 Nov;10(2-3):223-53.



10:  Aluminium complexing enhances amyloid beta protein  penetration of blood-brain barrier

Banks WA et al.

Brain Res. 2006 Oct  20;1116(1):215-21.



11:  Some aspects of astroglial functions and aluminium  implications for neurodegeneration

Aremu DA, Meshitsuka S.

Brain Res Rev. 2006 Aug  30;52(1):193-200.



12: Nanomolar aluminium induces pro-inflammatory and pro-apoptotic  gene expression in human brain cells in primary culture

Lukiw WJ et al.

J Inorg Biochem. 2005  Sep;99(9):1895-8.



13. Long-term persistence of vaccine-derived aluminum hydroxide is associated with chronic cognitive dysfunction

Maryline Couette et al.

Journal of Inorganic Biochemistry (2009) in press



14. Aluminium hydroxide injections lead to motor deficits and motor neuron degeneration

Christopher A. Shaw; Michael S. Petrik.

Journal of Inorganic Biochemistry (2009) in press



15. Biochemical and molecular basis of thimerosal-induced apoptosis in T cells: a major role of mitochondrial pathway

Makani S et al.

Genes Immun. 2002 Aug;3(5):270-8.

{free online}

http://www.nature.com/gene/journal/v3/n5/abs/6363854a.html



16. Thimerosal induces neuronal cell apoptosis by causing cytochrome c and apoptosis-inducing factor release from mitochondria

Yel L et al.

Int J Mol Med. 2005 Dec;16(6):971-7.



17. Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors

James SJ et al.

Neurotoxicology. 2005 Jan;26(1):1-8.



Thimerosol is an antiseptic containing 49.5% ethyl mercury that has been used for years as a preservative in many infant vaccines and in flu vaccines. Environmental methyl mercury has been shown to be highly neurotoxic, especially to the developing brain. Because mercury has a high affinity for thiol (sulfhydryl (-SH)) groups, the thiol-containing antioxidant, glutathione (GSH), provides the major intracellular defense against mercury-induced neurotoxicity. Cultured neuroblastoma cells were found to have lower levels of GSH and increased sensitivity to thimerosol toxicity compared to glioblastoma cells that have higher basal levels of intracellular GSH. Thimerosal-induced cytotoxicity was associated with depletion of intracellular GSH in both cell lines. Pretreatment with 100 microM glutathione ethyl ester or N-acetylcysteine (NAC), but not methionine, resulted in a significant increase in intracellular GSH in both cell types. Further, pretreatment of the cells with glutathione ethyl ester or NAC prevented cytotoxicity with exposure to 15 microM Thimerosal. Although Thimerosal has been recently removed from most children's vaccines, it is still present in flu vaccines given to pregnant women, the elderly, and to children in developing countries. The potential protective effect of GSH or NAC against mercury toxicity warrants further research as possible adjunct therapy to individuals still receiving Thimerosal-containing vaccinations.